| URL: | http://www.hepamine.de |
| Full name: | A Liver Disease Microarray Database |
| Description: | Hepamine was designed as a web-based repository of pre-analyzed microarray data for various liver diseases. Among these are HCC, CCC, liver cirrhosis, chronic hepatitis B and C, or biliary atresia. In contrast to public microarray repositories our website offers open and easy access to the respective, pre-analyzed gene expression profiles and support to compare samples, experiments and various liver diseases. Genes may be searched on the basis of specific expression patterns across diverse samples. All may be obtained as a simple three color table indicating up-, down-, or no differential expression in multiple experiments. |
| Year founded: | 2020 |
| Last update: | 2020-03-16 |
| Version: | 1.0 |
| Accessibility: |
Accessible
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| Country/Region: | Germany |
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| University/Institution: | Heidelberg University |
| Address: | Division of Hepatology, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany |
| City: | Heidelberg |
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| Country/Region: | Germany |
| Contact name (PI/Team): | Andreas Teufel |
| Contact email (PI/Helpdesk): | andreas.teufel@medma.uni-heidelberg.de |
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Hepamine - A Liver Disease Microarray Database, Visualization Platform and Data-Mining Resource. [PMID: 32179762]
Numerous gene expression profiling data on liver diseases were generated and stored in public databases. Only few were used for additional analyses by the hepatology research community. This may mostly be due to limited bioinformatics knowledge of most biomedical research personnel. In order to support an easy translation of bioinformatics data into translational hepatology research, we created Hepamine, a liver disease gene expression, visualization platform and data-mining resource. Microarray data were obtained from the NCBI GEO database. Pre-analysis of expression data was performed using R statistical software and the limma microarray analysis package from the Bioconductor repository. We generated Hepamine, a web-based repository of pre-analyzed microarray data for various liver diseases. At its initial release Hepamine contains 13 gene expression datasets, 20 microarray experiments and approximately 400 000 gene expression measurements. A self-explanatory website offers open and easy access to gene expression profiles. Results are furthermore visualized in simple three-color tables indicating differential expression. All data were linked to common functional and genetic databases particularly through the DAVID bioinformatics suite. Hepamine provides comprehensive data and easy access to hepatologic gene expression data even without in depth bioinformatics or microarray profiling experience. http://www.hepamine.de. |