| URL: | http://clingen.igib.res.in/esc |
| Full name: | Immune escape variants in SARS-CoV-2 |
| Description: | Esc (Immune escape variants in SARS-CoV-2) is a comprehensive and manually curated compendium of genetic variants in SARS-CoV-2 associated with immune escape. The data on variants and associations have been compiled from published literature as well as preprints and includes a variety of antibodies ranging from monoclonal as well as oligoclonal and convalescent plasma panels. |
| Year founded: | 2021 |
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| Country/Region: | India |
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| University/Institution: | CSIR - Institute of Genomics and Integrative Biology |
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| Country/Region: | India |
| Contact name (PI/Team): | Vinod Scaria |
| Contact email (PI/Helpdesk): | vinods@igib.in |
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ESC: a comprehensive resource for SARS-CoV-2 immune escape variants. [PMID: 34643704]
Ever since the breakout of COVID-19 disease, ceaseless genomic research to inspect the epidemiology and evolution of the pathogen has been undertaken globally. Large scale viral genome sequencing and analysis have uncovered the functional impact of numerous genetic variants in disease pathogenesis and transmission. Emerging evidence of mutations in spike protein domains escaping antibody neutralization is reported. We have built a database with precise collation of manually curated variants in SARS-CoV-2 from literature with potential escape mechanisms from a range of neutralizing antibodies. This comprehensive repository encompasses a total of 5258 variants accounting for 2068 unique variants tested against 230 antibodies, patient convalescent plasma and vaccine breakthrough events. This resource enables the user to gain access to an extensive annotation of SARS-CoV-2 escape variants which would contribute to exploring and understanding the underlying mechanisms of immune response against the pathogen. The resource is available at http://clingen.igib.res.in/esc/. |