Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database Profile

General information

URL: http://180.208.58.19/RMDisease/index.html
Full name:
Description: A database of genetic variants that affect RNA modifications, with implications for epitranscriptome pathogenesis
Year founded: 2021
Last update:
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Country/Region: China
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Contact information

University/Institution: Xi’an Jiaotong-Liverpool University
Address: Department of Biological Sciences, Xi’an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China
City: Suzhou
Province/State: Jiangsu
Country/Region: China
Contact name (PI/Team): Jia Meng
Contact email (PI/Helpdesk): jia.meng@xjtlu.edu.cn

Publications

33010174
RMDisease: a database of genetic variants that affect RNA modifications, with implications for epitranscriptome pathogenesis. [PMID: 33010174]
Chen K, Song B, Tang Y, Wei Z, Xu Q, Su J, de Magalhães JP, Rigden DJ, Meng J.

Deciphering the biological impacts of millions of single nucleotide variants remains a major challenge. Recent studies suggest that RNA modifications play versatile roles in essential biological mechanisms, and are closely related to the progression of various diseases including multiple cancers. To comprehensively unveil the association between disease-associated variants and their epitranscriptome disturbance, we built RMDisease, a database of genetic variants that can affect RNA modifications. By integrating the prediction results of 18 different RNA modification prediction tools and also 303,426 experimentally-validated RNA modification sites, RMDisease identified a total of 202,307 human SNPs that may affect (add or remove) sites of eight types of RNA modifications (m6A, m5C, m1A, m5U, Ψ, m6Am, m7G and Nm). These include 4,289 disease-associated variants that may imply disease pathogenesis functioning at the epitranscriptome layer. These SNPs were further annotated with essential information such as post-transcriptional regulations (sites for miRNA binding, interaction with RNA-binding proteins and alternative splicing) revealing putative regulatory circuits. A convenient graphical user interface was constructed to support the query, exploration and download of the relevant information. RMDisease should make a useful resource for studying the epitranscriptome impact of genetic variants via multiple RNA modifications with emphasis on their potential disease relevance. RMDisease is freely accessible at: www.xjtlu.edu.cn/biologicalsciences/rmd.

Nucleic Acids Res. 2021:49(D1) | 9 Citations (from Europe PMC, 2021-11-27)

Ranking

All databases:
1017/5113 (80.129%)
Modification:
55/231 (76.623%)
Health and medicine:
217/1093 (80.238%)
1017
Total Rank
9
Citations
9
z-index

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Record metadata

Created on: 2021-11-15
Curated by:
lin liu [2021-11-15]