Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

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Description: A comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment.
Year founded: 2021
Last update:
Real time : Checking...
Country/Region: China
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Contact information

University/Institution: Tongji University
Address: Shanghai Putuo District People’s Hospital, School of Life Science and Technology, Tongji University, Shanghai 200060, China
Country/Region: China
Contact name (PI/Team): Chenfei Wang
Contact email (PI/Helpdesk):


TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment. [PMID: 33179754]
Sun D, Wang J, Han Y, Dong X, Ge J, Zheng R, Shi X, Wang B, Li Z, Ren P, Sun L, Yan Y, Zhang P, Zhang F, Li T, Wang C.

Cancer immunotherapy targeting co-inhibitory pathways by checkpoint blockade shows remarkable efficacy in a variety of cancer types. However, only a minority of patients respond to treatment due to the stochastic heterogeneity of tumor microenvironment (TME). Recent advances in single-cell RNA-seq technologies enabled comprehensive characterization of the immune system heterogeneity in tumors but posed computational challenges on integrating and utilizing the massive published datasets to inform immunotherapy. Here, we present Tumor Immune Single Cell Hub (TISCH,, a large-scale curated database that integrates single-cell transcriptomic profiles of nearly 2 million cells from 76 high-quality tumor datasets across 27 cancer types. All the data were uniformly processed with a standardized workflow, including quality control, batch effect removal, clustering, cell-type annotation, malignant cell classification, differential expression analysis and functional enrichment analysis. TISCH provides interactive gene expression visualization across multiple datasets at the single-cell level or cluster level, allowing systematic comparison between different cell-types, patients, tissue origins, treatment and response groups, and even different cancer-types. In summary, TISCH provides a user-friendly interface for systematically visualizing, searching and downloading gene expression atlas in the TME from multiple cancer types, enabling fast, flexible and comprehensive exploration of the TME.

Nucleic Acids Res. 2021:49(D1) | 19 Citations (from Europe PMC, 2021-11-27)


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508/5113 (90.084%)
77/941 (91.923%)
Health and medicine:
111/1093 (89.936%)
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Created on: 2021-11-15
Curated by:
lin liu [2021-11-15]