Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database Profile

General information

Full name:
Description: MitImpact is a collection of genomic, clinical and functional annotations for all nucleotide changes that cause non-synonymous substitutions in human mitochondrial protein coding genes
Year founded: 2015
Last update: 2021
Real time : Checking...
Country/Region: Italy
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Contact information

University/Institution: IRCCS Casa Sollievo della Sofferenza
Address: Laboratory of Bioinformatics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), 71013, Italy
Country/Region: Italy
Contact name (PI/Team): Tommaso Mazza
Contact email (PI/Helpdesk):


MitImpact 3: modeling the residue interaction network of the Respiratory Chain subunits. [PMID: 33300029]
Castellana S, Biagini T, Petrizzelli F, Parca L, Panzironi N, Caputo V, Vescovi AL, Carella M, Mazza T.

Numerous lines of evidence have shown that the interaction between the nuclear and mitochondrial genomes ensures the efficient functioning of the OXPHOS complexes, with substantial implications in bioenergetics, adaptation, and disease. Their interaction is a fascinating and complex trait of the eukaryotic cell that MitImpact explores with its third major release. MitImpact expands its collection of genomic, clinical, and functional annotations of all non-synonymous substitutions of the human mitochondrial genome with new information on putative Compensated Pathogenic Deviations and co-varying amino acid sites of the Respiratory Chain subunits. It further provides evidence of energetic and structural residue compensation by techniques of molecular dynamics simulation. MitImpact is freely accessible at

Nucleic Acids Res. 2021:49(D1) | 2 Citations (from Europe PMC, 2021-11-27)
MitImpact: an exhaustive collection of pre-computed pathogenicity predictions of human mitochondrial non-synonymous variants. [PMID: 25516408]
Stefano Castellana, Judit Rónai, Tommaso Mazza,

Mitochondrial DNA carries a tiny, but fundamental portion of the eukaryotic genetic code. As its nuclear counterpart, it is susceptible to point mutations. Their level of pathogenicity has been assessed for the newly discovered mutations only, leaving some degree of uncertainty on the potential impact of the unknown mutations. Here we present Mitochondrial mutation Impact (MitImpact), a queryable lightweight web interface to a reasoned collection of structurally and evolutionary annotated pathogenicity predictions, obtained by assembling pre-computed with on-the-fly-computed sets of pathogenicity estimations, for all the possible mitochondrial missense variants. It presents itself as a resource for fast and reliable evaluation of gene-specific susceptibility of unknown and verified amino acid changes. MitImpact is freely available at (tools section). ©2014 Wiley Periodicals, Inc.

Hum. Mutat.. 2015:36(2) | 28 Citations (from Europe PMC, 2021-11-27)


All databases:
1643/5113 (67.886%)
Gene genome and annotation:
487/1358 (64.212%)
Health and medicine:
344/1093 (68.618%)
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Created on: 2021-11-15
Curated by:
lin liu [2021-11-15]