| URL: | https://webs.iiitd.edu.in/raghava/b3pdb |
| Full name: | blood–brain barrier-penetrating peptides database |
| Description: | B3Pdb is a database of Blood Brain Barrier crossing Peptides, it contains around 465 unique Blood Brain Barrier penetrating Peptides (B3PPs) alongwith their secondary and tertiary structure. This database maintains experimentally validated B3PPs. |
| Year founded: | 2021 |
| Last update: | |
| Version: | |
| Accessibility: |
Accessible
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| Country/Region: | India |
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| University/Institution: | Indraprastha Institute of Information Technology |
| Address: | Professor & Head Department of Computational Biology, Indraprastha Institute of Information Technology, Okhla Phase 3, New Delhi, India. |
| City: | New Delhi |
| Province/State: | |
| Country/Region: | India |
| Contact name (PI/Team): | Dr. Gajendra P. S. Raghava |
| Contact email (PI/Helpdesk): | raghava@iiitd.ac.in |
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B3Pdb: an archive of blood-brain barrier-penetrating peptides. [PMID: 34269889]
The blood-brain barrier poses major hurdles in the treatment of brain-related ailments. Over the past decade, interest in peptides-based therapeutics has thrived a lot because of their higher benefit to risk ratio. However, a complete knowledgebase providing a well-annotated picture of the peptide as a therapeutic molecule to cure brain-related ailments is lacking. We have built up a knowledgebase B3Pdb on blood-brain barrier (BBB)-penetrating peptides in the present study. The B3Pdb holds clinically relevant experimental information on 1225 BBB-penetrating peptides, including mode of delivery, animal model, in vitro/in vivo experiments, chemical modifications, length. Hoping that drug delivery systems can improve central nervous system disorder-related therapeutics. In this regard, B3Pdb is an important resource to support the rational design of therapeutics peptides for CNS-related disorders. The complete ready-to-use and updated database with a user-friendly web interface is available to the scientific community at https://webs.iiitd.edu.in/raghava/b3pdb/ . |