| URL: | http://reva.gao-lab.org |
| Full name: | Repository for Expression-modulating VAriants |
| Description: | REVA is a database specifically designed for storing experimentally validated variants. |
| Year founded: | 2021 |
| Last update: | 2021-11-21 |
| Version: | v1.1 |
| Accessibility: |
Accessible
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| Country/Region: | China |
| Data type: | |
| Data object: | |
| Database category: | |
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| Keywords: |
| University/Institution: | Peking University |
| Address: | State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Biomedical Pioneering Innovation Center (BIOPIC) & Beijing Advanced Innovation Center for Genomics (ICG), Center for Bioinformatics (CBI), Peking University, Beijing 100871, China |
| City: | Beijing |
| Province/State: | |
| Country/Region: | China |
| Contact name (PI/Team): | Ge Gao |
| Contact email (PI/Helpdesk): | gaog@mail.cbi.pku.edu.cn |
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REVA as A Well-curated Database for Human Expression-modulating Variants. [PMID: 34224878]
More than 90% of disease- and trait-associated human variants are noncoding. By systematically screening multiple large-scale studies, we compiled REVA, a manually curated database for over 11.8 million experimentally tested noncoding variants with expression-modulating potentials. We provided 2424 functional annotations that could be used to pinpoint the plausible regulatory mechanism of these variants. We further benchmarked multiple state-of-the-art computational tools and found their limited sensitivity remains a serious challenge for effective large-scale analysis. REVA provides high-quality experimentally tested expression-modulating variants with extensive functional annotations, which will be useful for users in the noncoding variants community. REVA is available at http://reva.gao-lab.org. |