| URL: | http://fcgportal.org/TCSA |
| Full name: | The Cancer Surfaceome Atlas |
| Description: | The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets. |
| Year founded: | 2021 |
| Last update: | |
| Version: | |
| Accessibility: |
Accessible
|
| Country/Region: | United States |
| Data type: | |
| Data object: | |
| Database category: | |
| Major species: | |
| Keywords: |
| University/Institution: | University of Pennsylvania |
| Address: | |
| City: | |
| Province/State: | |
| Country/Region: | United States |
| Contact name (PI/Team): | linzhang |
| Contact email (PI/Helpdesk): | linzhang@upenn.edu |
|
The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets. [PMID: 35121907]
Cell-surface proteins (SPs) are a rich source of immune and targeted therapies. By systematically integrating single-cell and bulk genomics, functional studies and target actionability, in the present study we comprehensively identify and annotate genes encoding SPs (GESPs) pan-cancer. We characterize GESP expression patterns, recurrent genomic alterations, essentiality, receptor-ligand interactions and therapeutic potential. We also find that mRNA expression of GESPs is cancer-type specific and positively correlates with protein expression, and that certain GESP subgroups function as common or specific essential genes for tumor cell growth. We also predict receptor-ligand interactions substantially deregulated in cancer and, using systems biology approaches, we identify cancer-specific GESPs with therapeutic potential. We have made this resource available through the Cancer Surfaceome Atlas ( http://fcgportal.org/TCSA ) within the Functional Cancer Genome data portal. |