| URL: | http://bio-bigdata.hrbmu.edu.cn/rna2immune/home.jsp |
| Full name: | experimentally supported ncRNA and immune regulation associations database |
| Description: | Here, we describe a comprehensive database, RNA2Immune, which aims to provide a high-quality resource of experimentally supported associations linking ncRNA regulatory mechanisms to immune cell function, immune disease, cancer immunology, and vaccines. The current version of RNA2Immune documents 50,433 immune−ncRNA associations in 42 host species, including: (i) 6690 ncRNA associations with immune functions involving 31 immune cell types; (ii) 38,672 ncRNA associations with 348 immune diseases; (iii) 4833 ncRNA associations with cancer immunology; and (iv) 238 ncRNA associations with vaccine responses involving 26 vaccine types targeting 22 diseases. |
| Year founded: | 2022 |
| Last update: | 2022 |
| Version: | 1.0 |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Harbin Medical University |
| Address: | Department of Neurology, The Second Affiliated Hospital, Harbin Medical University 148 Baojian Road, Harbin 150081, China |
| City: | Harbin |
| Province/State: | HeiLongJiang |
| Country/Region: | China |
| Contact name (PI/Team): | Jianjian Wang |
| Contact email (PI/Helpdesk): | wangjian_427@163.com |
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RNA2Immune: A database of experimentally supported data linking non-coding RNA regulation to the immune system. [PMID: 35595213]
Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as important regulators of the immune system and are involved in the control of immune cell biology, disease pathogenesis, as well as vaccine responses. A repository of ncRNA-immune associations will facilitate our understanding of ncRNA-dependent mechanisms in the immune system and advance the development of therapeutics and prevention for immune disorders. Here, we describe a comprehensive database, RNA2Immune, which aims to provide a high-quality resource of experimentally supported database linking ncRNA regulatory mechanisms to immune cell function, immune disease, cancer immunology, and vaccines. The current version of RNA2Immune documents 50,433 immune-ncRNA associations in 42 host species, including: (1) 6690 ncRNA associations with immune functions involving 31 immune cell types; (2) 38,672 ncRNA associations with 348 immune diseases; (3) 4833 ncRNA associations with cancer immunology; and (4) 238 ncRNA associations with vaccine responses involving 26 vaccine types targeting 22 diseases. RNA2Immune provides a user-friendly interface for browsing, searching, and downloading ncRNA-immune system associations. Collectively, RNA2Immune provides important information about how ncRNAs influence immune cell function, how dysregulation of these ncRNAs leads to pathological consequences (immune diseases and cancers), and how ncRNAs affect immune responses to vaccines. RNA2Immune is available at http://bio-bigdata.hrbmu.edu.cn/rna2immune/home.jsp. |