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General information

Full name: Transcriptome-Wide Association Studies (TWAS) Atlas
Description: Transcriptome-Wide Association Studies (TWAS) Atlas is a curated knowledgebase of transcriptome-wide association studies, integrating trait-associated transcriptome signals from TWAS publications and constructing TWAS knowledge graph to provide reliable and practical resource for researchers.
Year founded: 2022
Last update: 2022
Version: V1
Real time : Checking...
Country/Region: China

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Contact information

University/Institution: Beijing Institute of Genomics, Chinese Academy of Sciences
City: Beijing
Province/State: Beijing
Country/Region: China
Contact name (PI/Team): Xiao Jingfa
Contact email (PI/Helpdesk):


TWAS Atlas: a curated knowledgebase of transcriptome-wide association studies. [PMID: 36243959]
Lu M, Zhang Y, Yang F, Mai J, Gao Q, Xu X, Kang H, Hou L, Shang Y, Qain Q, Liu J, Jiang M, Zhang H, Bu C, Wang J, Zhang Z, Zhang Z, Zeng J, Li J, Xiao J.

Transcriptome-wide association studies (TWASs), as a practical and prevalent approach for detecting the associations between genetically regulated genes and traits, are now leading to a better understanding of the complex mechanisms of genetic variants in regulating various diseases and traits. Despite the ever-increasing TWAS outputs, there is still a lack of databases curating massive public TWAS information and knowledge. To fill this gap, here we present TWAS Atlas (, an integrated knowledgebase of TWAS findings manually curated from extensive literature. In the current implementation, TWAS Atlas collects 401,266 high-quality human gene-trait associations from 200 publications, covering 22,247 genes and 257 traits across 135 tissue types. In particular, an interactive knowledge graph of the collected gene-trait associations is constructed together with single nucleotide polymorphism (SNP)-gene associations to build up comprehensive regulatory networks at multi-omics levels. In addition, TWAS Atlas, as a user-friendly web interface, efficiently enables users to browse, search and download all association information, relevant research metadata and annotation information of interest. Taken together, TWAS Atlas is of great value for promoting the utility and availability of TWAS results in explaining the complex genetic basis as well as providing new insights for human health and disease research.

Nucleic Acids Res. 2022:() | 1 Citations (from Europe PMC, 2023-09-23)



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Created on: 2022-12-08
Curated by:
Lina Ma [2022-12-08]
Dong Zou [2022-12-08]
Jingfa Xiao [2022-12-08]