| URL: | https://esslnc.pufengdu.org |
| Full name: | essential lncRNA database |
| Description: | dbEssLnc manually collects and collates essential lncRNAs information from existing databases and published literature. dbEssLnc also provides a platform to perform some simple comparative analysis between human and mouse essential lncRNAs. dbEssLnc database contains 207 essential lncRNAs, including 40 general essential lncRNAs, 69 lncRNA tumor suppressor genes, and 98 lncRNA oncogenes. |
| Year founded: | 2022 |
| Last update: | 2022-05-17 |
| Version: | v1.0 |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Tianjin University |
| Address: | College of Intelligence and Computing, Tianjin University, Tianjin 300350, China |
| City: | Tianjin |
| Province/State: | Hebei |
| Country/Region: | China |
| Contact name (PI/Team): | PuFeng Du |
| Contact email (PI/Helpdesk): | pdu@tju.edu.cn |
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dbEssLnc: A manually curated database of human and mouse essential lncRNA genes. [PMID: 35685362]
Long non-coding RNAs (lncRNAs) play important roles in many biological processes. Knocking out or knocking down some lncRNAs will lead to lethality or infertility. These lncRNAs are called essential lncRNAs. Knowledges of essential lncRNAs are important in establishing minimal genomes of living cells, developing drug therapies and early diagnostic approaches for complex diseases. However, existing databases focus on collecting essential coding genes. Essential non-coding gene records are rare in existing databases. A comprehensive collection of essential non-coding genes, particularly essential lncRNA genes, is demanded. We manually curated 207 essential lncRNAs from literatures for establishing a database on essential lncRNAs, which is named as dbEssLnc (Database of essential lncRNAs). The dbEssLnc database has a web-based user-friendly interface for the users to browse, to search, to visualize and to blast search records in the database. The dbEssLnc database is freely accessible at https://esslnc.pufengdu.org. All data and source codes for mirroring the dbEssLnc database have been deposited in GitHub (https://github.com/yyZhang14/dbEssLnc). |