| URL: | https://hanlab.uth.edu/HeRA/ |
| Full name: | human enhancer RNA atlas |
| Description: | HeRA characterizes the expression landscape of enhancer RNA (eRNA) across 54 human tissues, and provides four modules to explore eRNAs: expression, associated traits, potential regulators, and potential target genes across human tissues. HeRA identifies 45,411 eRNA from 9,577 samples across 54 human tissues from GTEx Project. Annotations of enhancers are collected from ENCODE, FANTOM and Roadmap Epigenomics Project. |
| Year founded: | 2021 |
| Last update: | 2020 |
| Version: | v1.0 |
| Accessibility: |
Accessible
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| Country/Region: | United States |
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| University/Institution: | The University of Texas Health Science Center at Houston |
| Address: | Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX 77030, USA |
| City: | Houston |
| Province/State: | Texas |
| Country/Region: | United States |
| Contact name (PI/Team): | Leng Han |
| Contact email (PI/Helpdesk): | Leng.Han@uth.tmc.edu |
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HeRA: an atlas of enhancer RNAs across human tissues. [PMID: 33119754]
Enhancer RNA (eRNA) is a type of long non-coding RNA transcribed from DNA enhancer regions. Despite critical roles of eRNA in gene regulation, the expression landscape of eRNAs in normal human tissue remains unexplored. Using numerous samples from the Genotype-Tissue Expression project, we characterized 45 411 detectable eRNAs and identified tens of thousands of associations between eRNAs and traits, including gender, race, and age. We constructed a co-expression network to identify millions of putative eRNA regulators and target genes across different tissues. We further constructed a user-friendly data portal, Human enhancer RNA Atlas (HeRA, https://hanlab.uth.edu/HeRA/). In HeRA, users can search, browse, and download the eRNA expression profile, trait-related eRNAs, and eRNA co-expression network by searching the eRNA ID, gene symbol, and genomic region in one or multiple tissues. HeRA is the first data portal to characterize eRNAs from 9577 samples across 54 human tissues and facilitates functional and mechanistic investigations of eRNAs. |