| URL: | https://www.ribocentre.org |
| Full name: | a database of ribozymes |
| Description: | Ribocentre is designed to contain comprehensive information of all natural ribozymes. Ribozymes are good systems for understanding the ‘sequence - structure - function’ relationship of RNA molecules, since ribozymes are found in the genomes of species from all kingdoms of life and play a role in important reactions such as peptide-bond formation, RNA splicing, transfer RNA biosynthesis, and viral replication. This is therefore an excellent time to summarise these properties, and our new web-based database will make this generally accessible. |
| Year founded: | 2022 |
| Last update: | 2023-03-07 |
| Version: | v1.5 |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Sun Yat-Sen University |
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| Country/Region: | China |
| Contact name (PI/Team): | Lin Huang |
| Contact email (PI/Helpdesk): | huanglin36@mail.sysu.edu.cn |
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Ribocentre: a database of ribozymes. [PMID: 36177882]
Ribozymes are excellent systems in which to study 'sequence - structure - function' relationships in RNA molecules. Understanding these relationships may greatly help structural modeling and design of functional RNA structures and some functional structural modules could be repurposed in molecular design. At present, there is no comprehensive database summarising all the natural ribozyme families. We have therefore created Ribocentre, a database that collects together sequence, structure and mechanistic data on 21 ribozyme families. This includes available information on timelines, sequence families, secondary and tertiary structures, catalytic mechanisms, applications of the ribozymes together with key publications. The database is publicly available at https://www.ribocentre.org. |