| URL: | http://bionet.ncpsb.org.cn/dcabm-tcm/ |
| Full name: | a Database of Constituents Absorbed into Blood and Metabolites of Traditional Chinese Medicine |
| Description: | DCABM-TCM is a Database of Constituents Absorbed into Blood and Metabolites of Traditional Chinese Medicine, is the first database systematically collecting blood constituents of TCM prescriptions and herbs. In current DCABM-TCM, 1816 blood constituents with chemical structures of 194 herbs and 192 prescriptions were manually mined from literature, together with the detailed experimental conditions under which the blood constituents were detected, including extraction method, experimental animal and animal model, administration method and dose, blood collection time and location etc. In addition, 1893 blood constituents without structures were also been recorded in the DCABM-TCM as they were given in the source publications. |
| Year founded: | 2021 |
| Last update: | 2023-06 |
| Version: | v1.0 |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Beijing Institute of Lifeomics |
| Address: | State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China. |
| City: | Beijing |
| Province/State: | |
| Country/Region: | China |
| Contact name (PI/Team): | Zhongyang Liu |
| Contact email (PI/Helpdesk): | liuzy1984@163.com |
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DCABM-TCM: A Database of Constituents Absorbed into the Blood and Metabolites of Traditional Chinese Medicine. [PMID: 37486750]
Traditional Chinese medicine (TCM) not only maintains the health of Asian people but also provides a great resource of active natural products for modern drug development. Herein, we developed a Database of Constituents Absorbed into the Blood and Metabolites of TCM (DCABM-TCM), the first database systematically collecting blood constituents of TCM prescriptions and herbs, including prototypes and metabolites experimentally detected in the blood, together with the corresponding detailed detection conditions through manual literature mining. The DCABM-TCM has collected 1816 blood constituents with chemical structures of 192 prescriptions and 194 herbs and integrated their related annotations, including physicochemical, absorption, distribution, metabolism, excretion, and toxicity properties, and associated targets, pathways, and diseases. Furthermore, the DCABM-TCM supported two blood constituent-based analysis functions, the network pharmacology analysis for TCM molecular mechanism elucidation, and the target/pathway/disease-based screening of candidate blood constituents, herbs, or prescriptions for TCM-based drug discovery. The DCABM-TCM is freely accessible at http://bionet.ncpsb.org.cn/dcabm-tcm/. The DCABM-TCM will contribute to the elucidation of effective constituents and molecular mechanism of TCMs and the discovery of TCM-derived drug-like compounds that are both bioactive and bioavailable. |