| URL: | https://TEDD.obg.cuhk.edu.hk/ |
| Full name: | Temporal Expression during Development Database |
| Description: | The Temporal Expression during Development Database (TEDD) is an ongoing effort to build a comprehensive public resource to study tissue and temporally specific gene expression and regulation (accessible chromatins) during multiple developmental periods. Data were curated from publicly accessible datasets generated by molecular assays (bulk-sample RNA-seq, scRNA-seq and scATAC-seq) in samples originated from 79 non-diseased tissue sites across nearly 4,000 individuals. |
| Year founded: | 2022 |
| Last update: | 2022-06-20 |
| Version: | v1.0 |
| Accessibility: |
Accessible
|
| Country/Region: | China |
| Data type: | |
| Data object: | |
| Database category: | |
| Major species: | |
| Keywords: |
| University/Institution: | The Chinese University of Hong Kong, Shenzhen |
| Address: | Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China. |
| City: | |
| Province/State: | Hong Kong |
| Country/Region: | China |
| Contact name (PI/Team): | Elvis DONG |
| Contact email (PI/Helpdesk): | elvisdong@cuhk.edu.hk |
|
TEDD: a database of temporal gene expression patterns during multiple developmental periods in human and model organisms. [PMID: 36350663]
Characterization of the specific expression and chromatin profiles of genes enables understanding how they contribute to tissue/organ development and the mechanisms leading to diseases. Whilst the number of single-cell sequencing studies is increasing dramatically; however, data mining and reanalysis remains challenging. Herein, we systematically curated the up-to-date and most comprehensive datasets of sequencing data originating from 2760 bulk samples and over 5.1 million single-cells from multiple developmental periods from humans and multiple model organisms. With unified and systematic analysis, we profiled the gene expression and chromatin accessibility among 481 cell-types, 79 tissue-types and 92 timepoints, and pinpointed cells with the co-expression of target genes. We also enabled the detection of gene(s) with a temporal and cell-type specific expression profile that is similar to or distinct from that of a target gene. Additionally, we illustrated the potential upstream and downstream gene-gene regulation interactions, particularly under the same biological process(es) or KEGG pathway(s). Thus, TEDD (Temporal Expression during Development Database), a value-added database with a user-friendly interface, not only enables researchers to identify cell-type/tissue-type specific and temporal gene expression and chromatin profiles but also facilitates the association of genes with undefined biological functions in development and diseases. The database URL is https://TEDD.obg.cuhk.edu.hk/. |