URL: | http://bio-bigdata.hrbmu.edu.cn/IEAtlas |
Full name: | atlas of HLA-presented immunogenic epitopes derived from non-coding regions |
Description: | IEAtlas reanalyzed publicly available mass spectrometry-based HLA immunopeptidome datasets against our integrated benchmarked non-canonical open reading frame information. The current IEAtlas identified 245 870 non-canonical epitopes binding to HLA-I/II allotypes across 15 cancer types and 30 non-cancerous tissues, greatly expanding the cancer immunopeptidome. IEAtlas further evaluates the immunogenicity via several commonly used immunogenic features, including HLA binding affinity, stability and T-cell receptor recognition. In addition, IEAtlas provides the biochemical properties of epitopes as well as the clinical relevance of corresponding genes across major cancer types and normal tissues. |
Year founded: | 2023 |
Last update: | 2023-01-06 |
Version: | 1.0 |
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Accessible
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Country/Region: | China |
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University/Institution: | Harbin Medical University |
Address: | 194 Xuefu Road, Harbin 150081 |
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Country/Region: | China |
Contact name (PI/Team): | Juan Xu |
Contact email (PI/Helpdesk): | xujuanbiocc@ems.hrbmu.edu.cn |