| URL: | https://www.pancircbase.net |
| Full name: | Database for pancreatic islet circular RNAs |
| Description: | In this study, we analyzed publicly available RNA-sequencing datasets of the pancreatic islets to catalog all circRNAs expressed in pancreatic islets to construct the PanCircBase (https://www.pancircbase.net/) database that provides the following resources: 1) pancreatic islet circRNA annotation details (genomic position, host gene, exon information, splice length, sequence, other database IDs, cross-species conservation), 2) divergent primers for PCR analysis of circRNAs, 3) siRNAs for silencing of target circRNAs, 4) miRNAs associated with circRNAs, 5) possible protein-coding circRNAs and their polypeptides. In summary, this is a comprehensive online resource for exploring circRNA expression and its possible function in pancreatic β-cells. |
| Year founded: | 2022 |
| Last update: | 2022-04 |
| Version: | 1.0 |
| Accessibility: |
Accessible
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| Country/Region: | India |
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| University/Institution: | Institute of Life Sciences |
| Address: | Institute of Life Sciences, Nalco Square, Bhubaneswar, Odisha, India. |
| City: | Bhubaneswar |
| Province/State: | Odisha |
| Country/Region: | India |
| Contact name (PI/Team): | Amaresh Chandra Panda |
| Contact email (PI/Helpdesk): | amareshpanda@ils.res.in |
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PanCircBase: An online resource for the exploration of circular RNAs in pancreatic islets. [PMID: 36060809]
Circular RNAs (circRNAs) are a novel class of covalently closed RNA molecules that recently emerged as a critical regulator of gene expression in development and diseases. Recent research has highlighted the importance of novel circRNAs in the biosynthesis and secretion of insulin from β-cells of pancreatic islets. However, all circRNAs expressed in pancreatic islets or β-cells are not readily available in the database. In this study, we analyzed publicly available RNA-sequencing datasets of the pancreatic islets to catalog all circRNAs expressed in pancreatic islets to construct the PanCircBase (https://www.pancircbase.net/) database that provides the following resources: 1) pancreatic islet circRNA annotation details (genomic position, host gene, exon information, splice length, sequence, other database IDs, cross-species conservation), 2) divergent primers for PCR analysis of circRNAs, 3) siRNAs for silencing of target circRNAs, 4) miRNAs associated with circRNAs, 5) possible protein-coding circRNAs and their polypeptides. In summary, this is a comprehensive online resource for exploring circRNA expression and its possible function in pancreatic β-cells. |