MbPA


37086947	The Metal-binding Protein Atlas (MbPA): An Integrated Database for Curating Metalloproteins in All Aspects. [PMID: 37086947] Jinzhao Li, Xiang He, Shuang Gao, Yuchao Liang, Zhi Qi, Qilemuge Xi, Yongchun Zuo, Yongqiang Xing Abstract Metal-binding proteins are essential for the vital activities and engage in their roles by acting in concert with metal cations. MbPA (The Metal-binding Protein Atlas) is the most comprehensive resource up to now dedicated to curating metal-binding proteins. Currently, it contains 106,373 entries and 440,187 sites related to 54 metals and 8169 species. Users can view all metal-binding proteins and species-specific proteins in MbPA. There are also metal-proteomics data that quantitatively describes protein expression in different tissues and organs. By analyzing the data of the amino acid residues at the metal-binding site, it is found that about 80% of the metal ions tend to bind to cysteine, aspartic acid, glutamic acid, and histidine. Moreover, we use Diversity Measure to confirm that the diversity of metal-binding is specific in different area of periodic table, and further elucidate the binding modes of 19 transition metals on 20 amino acids. In addition, MbPA also embraces 6855 potential pathogenic mutations related to metalloprotein. The resource is freely available at http://bioinfor.imu.edu.cn/mbpa. J Mol Biol. 2023:435(14) \| 5 Citations (from Europe PMC, 2025-03-22)

The Metal-binding Protein Atlas (MbPA): An Integrated Database for Curating Metalloproteins in All Aspects. [PMID: 37086947]

Jinzhao Li, Xiang He, Shuang Gao, Yuchao Liang, Zhi Qi, Qilemuge Xi, Yongchun Zuo, Yongqiang Xing

Abstract

Metal-binding proteins are essential for the vital activities and engage in their roles by acting in concert with metal cations. MbPA (The Metal-binding Protein Atlas) is the most comprehensive resource up to now dedicated to curating metal-binding proteins. Currently, it contains 106,373 entries and 440,187 sites related to 54 metals and 8169 species. Users can view all metal-binding proteins and species-specific proteins in MbPA. There are also metal-proteomics data that quantitatively describes protein expression in different tissues and organs. By analyzing the data of the amino acid residues at the metal-binding site, it is found that about 80% of the metal ions tend to bind to cysteine, aspartic acid, glutamic acid, and histidine. Moreover, we use Diversity Measure to confirm that the diversity of metal-binding is specific in different area of periodic table, and further elucidate the binding modes of 19 transition metals on 20 amino acids. In addition, MbPA also embraces 6855 potential pathogenic mutations related to metalloprotein. The resource is freely available at http://bioinfor.imu.edu.cn/mbpa.

J Mol Biol. 2023:435(14) | 5 Citations (from Europe PMC, 2025-03-22)

URL:	http://bioinfor.imu.edu.cn/mbpa
Full name:	The Metal-binding Protein Atlas
Description:	MbPA (The Metal-binding Protein Atlas) is a comprehensive resource up to now dedicated to curating metal-binding proteins. Currently, it contains 106,373 entries and 440,187 sites related to 54 metals and 8169 species.
Year founded:	2020
Last update:
Version:
Accessibility:	Accessible
Country/Region:	China

Data type:	Protein
Data object:	Animal Archaea Bacteria Plant Virus
Database category:	Expression Structure
Major species:	Homo sapiens Mus musculoides Oryza sativa Zea mays
Keywords:	species-specific proteins metal-binding proteins protein expression in different tissues and organs

University/Institution:	Inner Mongolia University
Address:	The Key Laboratory of Mammalian Reproductive Biology and Biotechnology of the Ministry of Education, College of Life Sciences, Inner Mongolia University, Hohhot 010021, China
City:
Province/State:	Inner Mongolia
Country/Region:	China
Contact name (PI/Team):	Yongchun Zuo
Contact email (PI/Helpdesk):	yczuo@imu.edu.cn

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Database Commons a catalog of worldwide biological databases