| URL: | https://maayanlab.cloud/lncHUB2 |
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| Description: | Based on gene-gene co-expression correlations created from ARCHS4's processed RNA-seq samples, lncHUB2 presents 18,705 human and 11,274 mouse landing pages for long non-coding RNAs that include expression statistics across tissues and cell lines, predicted biological functions, pathway membership, subcellular localization, and predicted small molecules and CRISPR KO genes that may regulate their expression. |
| Year founded: | 2023 |
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| Accessibility: |
Accessible
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| Country/Region: | United States |
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| University/Institution: | Icahn School of Medicine at Mount Sinai |
| Address: | Giacomo B Marino, Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA |
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| Country/Region: | United States |
| Contact name (PI/Team): | Avi Ma’ayan |
| Contact email (PI/Helpdesk): | avi.maayan@mssm.edu |
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lncHUB2: aggregated and inferred knowledge about human and mouse lncRNAs. [PMID: 36869839]
Long non-coding ribonucleic acids (lncRNAs) account for the largest group of non-coding RNAs. However, knowledge about their function and regulation is limited. lncHUB2 is a web server database that provides known and inferred knowledge about the function of 18 705 human and 11 274 mouse lncRNAs. lncHUB2 produces reports that contain the secondary structure fold of the lncRNA, related publications, the most correlated coding genes, the most correlated lncRNAs, a network that visualizes the most correlated genes, predicted mouse phenotypes, predicted membership in biological processes and pathways, predicted upstream transcription factor regulators, and predicted disease associations. In addition, the reports include subcellular localization information; expression across tissues, cell types, and cell lines, and predicted small molecules and CRISPR knockout (CRISPR-KO) genes prioritized based on their likelihood to up- or downregulate the expression of the lncRNA. Overall, lncHUB2 is a database with rich information about human and mouse lncRNAs and as such it can facilitate hypothesis generation for many future studies. The lncHUB2 database is available at https://maayanlab.cloud/lncHUB2. Database URL: https://maayanlab.cloud/lncHUB2. |