| URL: | http://www.onethird-lab.com/gems |
| Full name: | Genetic variation Effects on Macromolecular Structure |
| Description: | GEMS introduces the research progress of the effects of genetic variation on the structure of biological macromolecules. GEMS aims to help researchers understand the knowledge of the effect of genetic variation on macromolecular structure and the development history of molecular structure prediction under the influence of genetic variation as soon as possible. |
| Year founded: | 2024 |
| Last update: | 2024-01-10 |
| Version: | v1.0 |
| Accessibility: |
Accessible
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| Country/Region: | China |
| Data type: | |
| Data object: |
NA
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| Database category: | |
| Major species: |
NA
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| Keywords: |
| University/Institution: | Harbin Medical University |
| Address: | College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China |
| City: | Harbin |
| Province/State: | Heilongjiang |
| Country/Region: | China |
| Contact name (PI/Team): | Yongshuai Jiang |
| Contact email (PI/Helpdesk): | jiangyongshuai@gmail.com |
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Effects of genetic variation on the structure of RNA and protein. [PMID: 38197532]
Changes in the structure of RNA and protein, have an important impact on biological functions and are even important determinants of disease pathogenesis and treatment. Some genetic variations, including copy number variation, single nucleotide variation, and so on, can lead to changes in biological function and increased susceptibility to certain diseases by changing the structure of RNA or protein. With the development of structural biology and sequencing technology, a large amount of RNA and protein structure data and genetic variation data resources has emerged to be used to explain biological processes. Here, we reviewed the effects of genetic variation on the structure of RNAs and proteins, and investigated their impact on several diseases. An online resource (http://www.onethird-lab.com/gems/) to support convenient retrieval of common tools is also built. Finally, the challenges and future development of the effects of genetic variation on RNA and protein were discussed. |