| URL: | http://xozhanglab.com/TETSS |
| Full name: | TE-TSS |
| Description: | TE-TSS identifies both de novo transcription start sites (TSSs) and transposon (TE) - derived TSSs from RNA-seq datasets in human and mouse. Within TE-TSS, you can explore the utilization of TSSs across different cell types, and gain deeper insights into the evolution and functionality of TE-derived TSS regions. |
| Year founded: | 2023 |
| Last update: | 2023 |
| Version: | v1.0 |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Tongji University |
| Address: | Shanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China |
| City: | |
| Province/State: | Shanghai |
| Country/Region: | China |
| Contact name (PI/Team): | Xiao-Ou Zhang |
| Contact email (PI/Helpdesk): | zhangxiaoou@tongji.edu.cn |
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TE-TSS: an integrated data resource of human and mouse transposable element (TE)-derived transcription start site (TSS). [PMID: 37956335]
Transposable elements (TEs) are abundant in the genome and serve as crucial regulatory elements. Some TEs function as epigenetically regulated promoters, and these TE-derived transcription start sites (TSSs) play a crucial role in regulating genes associated with specific functions, such as cancer and embryogenesis. However, the lack of an accessible database that systematically gathers TE-derived TSS data is a current research gap. To address this, we established TE-TSS, an integrated data resource of human and mouse TE-derived TSSs (http://xozhanglab.com/TETSS). TE-TSS has compiled 2681 RNA sequencing datasets, spanning various tissues, cell lines and developmental stages. From these, we identified 5768 human TE-derived TSSs and 2797 mouse TE-derived TSSs, with 47% and 38% being experimentally validated, respectively. TE-TSS enables comprehensive exploration of TSS usage in diverse samples, providing insights into tissue-specific gene expression patterns and transcriptional regulatory elements. Furthermore, TE-TSS compares TE-derived TSS regions across 15 mammalian species, enhancing our understanding of their evolutionary and functional aspects. The establishment of TE-TSS facilitates further investigations into the roles of TEs in shaping the transcriptomic landscape and offers valuable resources for comprehending their involvement in diverse biological processes. |