| URL: | http://spare4.hospital.studio:9000/lncPCD/Home.jsp |
| Full name: | LncPCD |
| Description: | The database includes detailed information on lncRNA regulatory mechanisms, PCD-associated cell types, lncRNA subcellular locations, and clinical applications. LncPCD also integrates single-cell sequencing datasets to explore the dynamics of lncRNAs in diseases, serving as a valuable resource for researchers studying lncRNA-mediated PCD and its role in various diseases. |
| Year founded: | 2023 |
| Last update: | 2023-11 |
| Version: | v1.0 |
| Accessibility: |
Accessible
|
| Country/Region: | China |
| Data type: | |
| Data object: | |
| Database category: | |
| Major species: | |
| Keywords: |
| University/Institution: | Harbin Medical University |
| Address: | 194 Xuefu Road, Harbin 150081, China |
| City: | Harbin |
| Province/State: | Heilongjiang |
| Country/Region: | China |
| Contact name (PI/Team): | Jianjian Wang |
| Contact email (PI/Helpdesk): | wangjian_427@163.com |
|
LncPCD: a manually curated database of experimentally supported associations between lncRNA-mediated programmed cell death and diseases. [PMID: 38011720]
Programmed cell death (PCD) refers to controlled cell death that is conducted to keep the internal environment stable. Long noncoding RNAs (lncRNAs) participate in the progression of PCD in a variety of diseases. However, no specialized online repository is available to collect and store the associations between lncRNA-mediated PCD and diseases. Here, we developed LncPCD, a comprehensive database that provides information on experimentally supported associations of lncRNA-mediated PCD with diseases. The current version of LncPCD documents 6666 associations between five common types of PCD (apoptosis, autophagy, ferroptosis, necroptosis and pyroptosis) and 1222 lncRNAs in 331 diseases. We also manually curated a wealth of information: (1) 7 important lncRNA regulatory mechanisms, (2) 310 PCD-associated cell types in three species, (3) detailed information on lncRNA subcellular locations and (4) clinical applications for lncRNA-mediated PCD in diseases. Additionally, 10 single-cell sequencing datasets were integrated into LncPCD to characterize the dynamics of lncRNAs in diseases. Overall, LncPCD is an extremely useful resource for understanding the functions and mechanisms of lncRNA-mediated PCD in diseases. Database URL: http://spare4.hospital.studio:9000/lncPCD/Home.jsp. |