| URL: | https://www.biosino.org/mpa |
| Full name: | Mycobacteriaceae Phenome Atlas |
| Description: | The Mycobacteriaceae Phenome Atlas (MPA) is a comprehensive database that compiles phenomic data for the Mycobacteriaceae family, including both pathogenic and nonpathogenic strains. It categorizes phenotypes into five main categories and explores the co-evolution of Mycobacterium tuberculosis with virulence factors, identifying pathogen-enriched pathways. |
| Year founded: | 2023 |
| Last update: | 2023 |
| Version: | v1.0 |
| Accessibility: |
Accessible
|
| Country/Region: | China |
| Data type: | |
| Data object: | |
| Database category: | |
| Major species: | |
| Keywords: |
| University/Institution: | Shanghai Institute of Nutrition and Health |
| Address: | National Genomics Data Center & Bio-Med Big Data Center, CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031 China. |
| City: | |
| Province/State: | Shanghai |
| Country/Region: | China |
| Contact name (PI/Team): | Guoping Zhao |
| Contact email (PI/Helpdesk): | gpzhao@sibs.ac.cn |
|
Mycobacteriaceae Phenome Atlas (MPA): A Standardized Atlas for the Mycobacteriaceae Phenome Based on Heterogeneous Sources. [PMID: 37881319]
The bacterial family Mycobacteriaceae includes pathogenic and nonpathogenic bacteria, and systematic research on their genome and phenome can give comprehensive perspectives for exploring their disease mechanism. In this study, the phenotypes of Mycobacteriaceae were inferred from available phenomic data, and 82 microbial phenotypic traits were recruited as data elements of the microbial phenome. This Mycobacteriaceae phenome contains five categories and 20 subcategories of polyphasic phenotypes, and three categories and eight subcategories of functional phenotypes, all of which are complementary to the existing data standards of microbial phenotypes. The phenomic data of Mycobacteriaceae strains were compiled by literature mining, third-party database integration, and bioinformatics annotation. The phenotypes were searchable and comparable from the website of the Mycobacteriaceae Phenome Atlas (MPA, https://www.biosino.org/mpa/). A topological data analysis of MPA revealed the co-evolution between Mycobacterium tuberculosis and virulence factors, and uncovered potential pathogenicity-associated phenotypes. Two hundred and sixty potential pathogen-enriched pathways were found by Fisher's exact test. The application of MPA may provide novel insights into the pathogenicity mechanism and antimicrobial targets of Mycobacteriaceae. Supplementary informationThe online version contains supplementary material available at 10.1007/s43657-023-00101-5. |