| URL: | https://gmsc.big-data-biology.org |
| Full name: | Global Microbial smORFs Catalogue |
| Description: | The global microbial smORF catalogue (GMSC) is an integrated, consistently-processed, smORFs catalogue of the microbial world, combining publicly available metagenomes and high-quality isolated microbial genomes. |
| Year founded: | 2024 |
| Last update: | 2024 |
| Version: | v1.0 |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Fudan University |
| Address: | Fudan University Zhangjiang Campus, No. 825 Zhangheng Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai, China |
| City: | Shanghai |
| Province/State: | Shanghai |
| Country/Region: | China |
| Contact name (PI/Team): | GMSC Team |
| Contact email (PI/Helpdesk): | 20110850018@fudan.edu.cn |
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A catalog of small proteins from the global microbiome. [PMID: 39214983]
Small open reading frames (smORFs) shorter than 100 codons are widespread and perform essential roles in microorganisms, where they encode proteins active in several cell functions, including signal pathways, stress response, and antibacterial activities. However, the ecology, distribution and role of small proteins in the global microbiome remain unknown. Here, we construct a global microbial smORFs catalog (GMSC) derived from 63,410 publicly available metagenomes across 75 distinct habitats and 87,920 high-quality isolate genomes. GMSC contains 965 million non-redundant smORFs with comprehensive annotations. We find that archaea harbor more smORFs proportionally than bacteria. We moreover provide a tool called GMSC-mapper to identify and annotate small proteins from microbial (meta)genomes. Overall, this publicly-available resource demonstrates the immense and underexplored diversity of small proteins. |