| URL: | https://shalab.njmu.edu.cn/humantestisdb/ |
| Full name: | a single-cell database for cells in human testicular microenvironment |
| Description: | HumanTestisDB is a comprehensive database for human testis, it consists of 46 single-cell sequencing datasets from human testis, covering ages from 6 weeks post-fertilization to 49 years old. After uniform analysis, a total of 131,113 cells were retained and classified into 38 different cell types. HumanTestisDB offers six cell sets, each focusing on critical biological events during spermatogenesis and providing in-depth cell type annotations. HumanTestisDB also elucidates cell-cell interactions within the testicular microenvironment across eight developmental stages, detailing the signaling pathways, receptor-ligand pairs, and the cell types involved in these interactions. In summary, HumanTestisDB provides invaluable insights into testicular transcriptomics and interactions, and serves as a vital tool for further research in reproductive biology. |
| Year founded: | 2025 |
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| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Nanjing Medical University |
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| Country/Region: | China |
| Contact name (PI/Team): | Yan Yuan |
| Contact email (PI/Helpdesk): | yuanyan@njmu.edu.cn |
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HumanTestisDB: A Comprehensive Atlas of Testicular Transcriptomics and Cellular Interactions. [PMID: 40045180]
Advances in single-cell technology have enabled the detailed mapping of testicular cell transcriptomes, which is essential for understanding spermatogenesis. However, the fragmented nature of age-specific data from various literature sources has hindered comprehensive analysis. To overcome this, the Human Testis Database (HumanTestisDB) was developed, consolidating multiple human testicular sequencing datasets to address this limitation. Through extensive investigation, 38 unique cell types were identified, providing a detailed perspective on cellular variety. Furthermore, the database systematically categorizes samples into eight developmental stages, offering a structured framework to comprehend the temporal dynamics of testicular development. Each stage features comprehensive maps of cell-cell interactions, elucidating the complex communication network inside the testicular microenvironment at particular developmental stages. Moreover, by facilitating comparisons of interactions among various cell types at different stages, the database permits examining alterations that transpire during critical transitions in spermatogenesis. HumanTestisDB, available at https://shalab.njmu.edu.cn/humantestisdb, offers vital insights into testicular transcriptomics and interactions, serving as an essential resource for advancing research in reproductive biology. |