| URL: | http://strchive.org |
| Full name: | short tandem repeat archive |
| Description: | STRchive is a dynamic, integrated database that consolidates information on disease-associated tandem repeat (TR) loci—including short tandem repeats (STRs) and variable number tandem repeats (VNTRs)—from research literature, clinical resources, and large-scale genomic datasets, facilitating the interpretation of TR variants in human disease. |
| Year founded: | 2025 |
| Last update: | 2025-03-26 |
| Version: | v1.0 |
| Accessibility: |
Accessible
|
| Country/Region: | United States |
| Data type: | |
| Data object: | |
| Database category: | |
| Major species: | |
| Keywords: |
| University/Institution: | University of Colorado Anschutz Medical Campus |
| Address: | |
| City: | Aurora |
| Province/State: | Colorado |
| Country/Region: | United States |
| Contact name (PI/Team): | Harriet Dashnow |
| Contact email (PI/Helpdesk): | harriet.dashnow@cuanschutz.edu |
|
STRchive: a dynamic resource detailing population-level and locus-specific insights at tandem repeat disease loci. [PMID: 40140942]
Approximately 8% of the human genome consists of repetitive elements called tandem repeats (TRs): short tandem repeats (STRs) of 1-6 bp motifs and variable number tandem repeats (VNTRs) of 7 + bp motifs. TR variants contribute to several dozen monogenic diseases but remain understudied and enigmatic. It remains comparatively challenging to interpret the clinical significance of TR variants, particularly relative to single nucleotide variants. We present STRchive ( http://strchive.org/ ), a dynamic resource consolidating information on TR disease loci from the research literature, up-to-date clinical resources, and large-scale genomic databases, streamlining TR variant interpretation at disease-associated loci. |