PURPOSE: This study explores the geographic distribution and ethnicity of Iranian patients with Thyroid Eye Disease (TED). It also analyzes semiology, the temporal relationship between thyroid dysfunction and TED, and concomitant diseases. An analysis of ocular visual and motility function in Iranian patients with TED at their initial presentation was also conducted.
METHODS: Data from the Iran TED Registry (IrTED) was extracted and analyzed to examine the demographics, clinical features, severity, and activity of TED. The study included patients who presented to the Rassoul Akram Hospital oculoplastic clinic in Tehran, Iran, between March 2020 and March 2023.
RESULTS: The database (https://orc.iums.ac.ir) included 685 patients (66.56% female), with congenital or acquired thyroid dysfunction/disease diagnosed with a mean age of 34.68 years (SD: 13.95, Range 0-78) and TED onset in the mean age of 37.79 years (SD: 14.06, Range: 2-78). Notably, 10.95% of patients developed TED before thyroid dysfunction, while 62.77% were diagnosed with thyroid dysfunction before the onset of TED. Elevated intraocular pressure (≥21 mmHg) in either eye was observed in 49 (7.15%) of participants, with 32 (4.67%) patients bilaterally involved. The distribution of registered patients by province of birth and ethnicity was also graphed. Semiology, coexisting health conditions, and visual and motility functions of patients were presented in a tabular format.
CONCLUSION: The successful implementation of IrTED contributes to a better understanding of TED epidemiology and semiology within the Iranian population.
