EDK
Editome Disease Knowledgebase
Depression
| Disease name | Depression |
|---|---|
| Classfication | Cognitive disorder |
| Related Enzyme(s) | |
| EFO | - |
| DOID | - |
| OMIM | |
| NCI | |
| Definition | Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, tendencies, feelings, and sense of well-being. |
| Gene symbol | Species | Enzyme | Editing site(s) | Editing Type | PMID | RADAR | REDIportal | Description |
|---|---|---|---|---|---|---|---|---|
| HTR2C | Human | ADAR1;ADAR2 | 6 | A-to-I | Dampening of serotonergic neurotransmission via RNA editing of 5-HT2C receptors. The research has identified that cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA. |