Disease - EDK - BIG Data Center

Disease name	Psoriasis
Classfication	Skin disease
Related Enzyme(s)
EFO	EFO:0000676
DOID	8893
OMIM	OMIM:601454 OMIM:602723 OMIM:603935 OMIM:604316 OMIM:605364 OMIM:605606 OMIM:607857 OMIM:610707 OMIM:612410 OMIM:612599 OMIM:612950
NCI	NCI:C3346
Definition

mRNA

Gene symbol	Species	Enzyme	Editing site(s)	Editing Type	PMID	RADAR	REDIportal	Description
FLNA	Human	ADAR1;ADAR2	1	NA	29592874			Decreased editing in highly conserved recoding sites in FLNA, might alter their function, leading to keratinocyte prolifera- tion, and impaired differentiation. And the decreased A-to-I ed- iting in keratinocytes could be involved in the exacerbation of psoriasis.