EDK
Editome Disease Knowledgebase
Systemic lupus erythematosus
| Disease name | Systemic lupus erythematosus |
|---|---|
| Classfication | other |
| Related Enzyme(s) | |
| EFO | |
| DOID | 9074 |
| OMIM |
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| NCI |
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| Definition | Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. |
| Gene symbol | Species | Enzyme | Editing site(s) | Editing Type | PMID | RADAR | REDIportal | Description |
|---|---|---|---|---|---|---|---|---|
| PDE8A | Human | ADAR1 | 5 | NA | Altered editing may contribute to the modulation of gene regulation and ultimately, immune functions in SLE and play an important role in the initiation and propagation of SLE pathogenesis;The observation of region-specific alterations of RNA editing of PDE8A in the cortex of suicide decedents with major depression raises the possibility of providing a marker for discriminating between suicides and control groups and suggests an immune response-related brain mechanism for suicide. |