LncRNA - EDK - BIG Data Center

LncRNA name	PCA3
Protein Name	Prostate Cancer Associated 3
Function	This gene produces a spliced, long non-coding RNA that is highly overexpressed in most types of prostate cancer cells and is used as a specific biomarker for this type of cancer. This gene is embedded in an intronic region of the prune2 gene on the opposite DNA strand. The transcript regulates prune2 levels through formation of a double-stranded RNA that undergoes adenosine deaminase acting on RNA-dependent adenosine-to-inosine RNA editing. In prostate cancer derived cells, overexpression of PCA induced downregulation of prune2, leading to decreased cell proliferation. Conversely, silencing in prostate cancer cells resulted in increased proliferation. Regulation of this gene appears to be sensitive to androgen-receptor activation, a molecular signature of prostate cancer. Alternative splicing results in multiple transcript variants.
Editing site(s)	1
RADAR
REDIportal
Description	ADAR1 proteins associate with PRUNE2/ PCA3 dsRNA and regulate PRUNE2 and PCA3 levels via A-to-I RNA editing. Edited PCA3 that down-regulates an unrecognized tumor suppressor gene, PRUNE2 (a human homolog of the Drosophila prune gene) thereby promoting prostate cancer malignant cell growth.
PMID	26080435

Enzyme	Editing Type	Editing Position	Molecular Consequence	Editing-Level	Target	Target Function	Editing Effect	Phenotype	PMID	Disease
ADAR1;ADAR2	A-to-I	87	Down-regulate the target gene	Present	PRUNE2	tumor suppressor gene	Edited PCA3 down-regulates tumor suppressor gene PRUNE2.	Promote prostate cancer malignant cell growth	26080435	Prostate Cancer;