EDK
Editome Disease Knowledgebase
ARPIN
| Gene symbol | ARPIN |
|---|---|
| Aliases | - |
| Protein Name | Arpin (Arp2/3 inhibition protein) |
| Function | Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation-promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence. |
| Species | Human |
| Editing Sites | 2 |
| Disease | Type 2 Diabetes; |
| Description | rs2028299, previously associated with type 2 diabetes, was an edQTL in the transcript of ARPIN, suggesting dysregulation of RNA editing as the cause of Increased disease risk |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | Q7Z6K5(Uniport); NM_182616 (NM id); 348110 (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | NT Seq Position | Editing Level | Tissue | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | 3'UTR | 1155 | Present | Artery aorta; Internal mammary artery; Whole blood; Subcutaneous fat; Visceral fat; Liver; | RNA editing of ARPIN is edQTL of rs2028299 which associated with type 2 diabetes. | Promote the disease risk | ||
|
A-to-I | 3'UTR | 1209 | Present | Artery aorta; Internal mammary artery; Whole blood; Subcutaneous fat; Visceral fat; Liver; | RNA editing of ARPIN is edQTL of rs2028299 which associated with type 2 diabetes. | Promote the disease risk |