EDK Editome Disease Knowledgebase

  1. Home
  2. RNA
  3. DHFR

DHFR

Gene symbol DHFR
Aliases -
Protein Name Dihydrofolate reductase
Function DHFR is a key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.
Species Human
Editing Sites 25
Disease Breast Cancer;
Description ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3 -UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate.
RADR RADAR
REDIportal REDI portal
External links P00374(Uniport); NM_000791 (NM id); 1719 (NCBI gene id); GeneCard; GTEx
Sequence

Editing sites

Enzyme Editing type Region NT Seq Position Molecular Consequence Editing Level Tissue Interaction Editing Effect Phenotype Disease name PMID
  • ADAR1
 A-to-I 3'UTR 1964 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 1972 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2043 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2050 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2056 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2089 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2096 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2102 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2105 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2107 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2119 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2136 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2174 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 G-to-A 3'UTR 2517 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2530 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2532 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2538 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2539 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2560 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2569 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2584 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2594 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2596 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2602 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation
  • ADAR1
 A-to-I 3'UTR 2603 mRNA expression change Increased Breast Cancer tissues; Adjacent Normal Tissues Enhance the cellular proliferation by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR ADAR1 positively regulates the expression of DHFR by editing the miR-25-3p and miR-125a-3p binding sites in the 3'UTR of DHFR, enhancing cellular proliferation and resistance to methotrexate. Promote tumor cell proliferation