EDK
Editome Disease Knowledgebase
FLNB
| Gene symbol | FLNB |
|---|---|
| Aliases | - |
| Protein Name | Filamin-B |
| Function | Filamin-B connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. |
| Species | Human |
| Editing Sites | 1 |
| Disease | Hepatocellular Carcinoma; Esophageal Squamous Cell Carcinoma; |
| Description | In the Hepatocellular Carcinoma samples and Esophageal Squamous Cell Carcinoma samples, FLNB demonstrate a higher editing level compare to the normal sample. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | O75369(Uniport); NM_001457 (NM id); 2317 (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | AA Seq Position | NT Seq Position | Codon Change | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | CDS | 2345 | 7135 | AUG->GUG | M->V | Nonsynonymous substitution | Present | Liver | The hyperediting of FLNB are closely associated with HCC pathogenesis. | Increase RNA editing level in disease | ||
|
A-to-I | CDS | 2345 | 7135 | AUG->GUG | M->V | Nonsynonymous substitution | Present | Esophageal | The hyperediting patterns of FLNB might play a role in ESCC progression. | Induce malignant phenotypes during tumor progression |