EDK
Editome Disease Knowledgebase
HNRPLL
| Gene symbol | HNRPLL |
|---|---|
| Aliases | SRRF; HNRPLL |
| Protein Name | Heterogeneous nuclear ribonucleoprotein L-like |
| Function | HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45, a tyrosine phosphatase essential for T-cell development and |
| Species | Human |
| Editing Sites | 3 |
| Disease | Tumor proliferation; |
| Description | ADARs-mediated RNA editing of the HNRPLL pre-mRNA determined its splicing pattern and linked to cell proliferation. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | (Uniport); (NM id); (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | NT Seq Position | Molecular Consequence | Editing Level | Tissue | Interaction | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | Intronic | chr2:38793330 | Alternative splicing | chr2:38793330(19) | HeLa and HEK293 cell lines | CCND1;TGFBR1 | ADARs-mediated RNA editing of the HNRPLL pre-mRNA determined its splicing pattern | RNA editing of HNRPLL generates a novel splicing variant linked to cell proliferation | ||
|
A-to-I | Intronic | chr2:38793318 | Alternative splicing | chr2:38793318(19) | HeLa and HEK293 cell lines | CCND1;TGFBR1 | ADARs-mediated RNA editing of the HNRPLL pre-mRNA determined its splicing pattern | RNA editing of HNRPLL generates a novel splicing variant linked to cell proliferation | ||
|
A-to-I | Intronic | chr2:38793328 | Alternative splicing | chr2:38793328(19) | HeLa and HEK293 cell lines | CCND1;TGFBR1 | ADARs-mediated RNA editing of the HNRPLL pre-mRNA determined its splicing pattern | RNA editing of HNRPLL generates a novel splicing variant linked to cell proliferation |