mRNA - EDK - BIG Data Center

HTR2C

Gene symbol	HTR2C
Aliases	-
Protein Name	5-hydroxytryptamine receptor 2C
Function	The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. Dampening of serotonergic neurotransmission via RNA editing of 5-HT2C receptors.
Species	Human
Editing Sites	6
Disease	Depression;
Description	Dampening of serotonergic neurotransmission via RNA editing of 5-HT2C receptors. The research has identified that cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA.
RADR	RADAR
REDIportal	REDI portal
External links	P28335(Uniport); NM_001256760 (NM id); 3358 (NCBI gene id); GeneCard; GTEx
Sequence

Editing sites

Enzyme	Editing type	Region	AA Seq Position	NT Seq Position	Codon Change	Amino Acid Change	Molecular Consequence	Editing Level	Tissue	Interaction	Editing Effect	Phenotype	Disease name	PMID
ADAR1 ADAR2	A-to-I	CDS	156	1287	AUA->GUA	I->V	Nonsynonymous substitution	Present	Brain	Dampen the quantity of serotonergic neurotransmission	Cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA.	Induce disease	Depression;	15093687
ADAR1 ADAR2	A-to-I	CDS	156	1289	AUA->AUG	I->M	Nonsynonymous substitution	Present	Brain	Dampen the quantity of serotonergic neurotransmission	Cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA.	Induce disease	Depression;	15093687
ADAR1 ADAR2	A-to-I	CDS	158	1292	AAU->AGU	N->S	Nonsynonymous substitution	Present	Brain	Dampen the quantity of serotonergic neurotransmission	Cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA.	Induce disease	Depression;	15093687
ADAR1 ADAR2	A-to-I	CDS	158	1291	AAU->GAU	N->D	Nonsynonymous substitution	Present	Brain	Dampen the quantity of serotonergic neurotransmission	Cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA.	Induce disease	Depression;	15093687
ADAR1 ADAR2	A-to-I	CDS	158	1292	AAU->GGU	N->G	Nonsynonymous substitution	Present	Brain	Dampen the quantity of serotonergic neurotransmission	Cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA.	Induce disease	Depression;	15093687
ADAR1 ADAR2	A-to-I	CDS	160	1300	AUU->GUU	I->V	Nonsynonymous substitution	Present	Brain	Dampen the quantity of serotonergic neurotransmission	Cytokines may induce depression at least in part through their effects on the editing of 5-HT2CR mRNA.	Induce disease	Depression;	15093687