EDK
Editome Disease Knowledgebase
NEIL1
| Gene symbol | NEIL1 |
|---|---|
| Aliases | - |
| Protein Name | Endonuclease 8-like 1 |
| Function | NEIL1 is a nvolved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. |
| Species | Human |
| Editing Sites | 1 |
| Disease | Lung Cancer; |
| Description | ADAR1 gene-amplified lung cancer cell lines show a higher frequency of A-to-I editing in NEIL1 relative to the ADAR1 normal copy number cells. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | Q96FI4(Uniport); NM_001256552 (NM id); 79661 (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | AA Seq Position | NT Seq Position | Codon Change | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Interaction | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | CDS | 242 | NA | AAG->AGG | K->R | Nonsynonymous substitution | Increased | Lung cancer tissues | Modify the miR-381 which implicated in stemness, chemoresistance and other cancer-relevant pathways | The edited NEIL1 transcripts significantly enhances the growth of tumor cells in comparison with the transfection of the unedited transcripts. | Increase RNA editing level in disease | ||
|
A-to-I | CDS | 242 | NA | AAG->AGG | K->R | Nonsynonymous substitution | Increased | Lung cancer tissues | Modify the miR-381 which implicated in stemness, chemoresistance and other cancer-relevant pathways | The edited NEIL1 transcripts significantly enhances the growth of tumor cells in comparison with the transfection of the unedited transcripts. | Increase RNA editing level in disease |