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PODXL

Gene symbol PODXL
Aliases -
Protein Name Podocalyxin
Function Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to Increased activities of the MAPK and PI3K pathways in cancer cells.
Species Human
Editing Sites 1
Disease Gastric Cancer;
Description RNA misediting is closely associated with GC pathogenesis, the ADAR2-regulated recoding PODXL gene at codon 241 (His to Arg) confers a loss-of-function phenotype that neutralizes the tumorigenic ability of the unedited PODXL.
RADR RADAR
REDIportal REDI portal
External links O00592(Uniport); NM_001018111 (NM id); 5420 (NCBI gene id); GeneCard; GTEx
Sequence

Editing sites

Enzyme Editing type Region AA Seq Position NT Seq Position Codon Change Amino Acid Change Molecular Consequence Editing Level Tissue Editing Effect Phenotype Disease name PMID
  • ADAR1
  • ADAR2
 A-to-I CDS 241 1091 CAG->CGG H->R Nonsynonymous substitution Absence Gastric RNA editing confers a loss-of-function phenotype that neutralizes the tumorigenic ability of the unedited PODXL. Reduce tumorigenic ability