EDK
Editome Disease Knowledgebase
RHOQ
| Gene symbol | RHOQ |
|---|---|
| Aliases | - |
| Protein Name | Rho-related GTP-binding protein RhoQ |
| Function | RHOQ (Ras Homolog Family Member Q) is a protein coding gene. Among its related pathways are ERK Signaling and Akt Signaling. RhoQ N136S amino acid substitution Increased RhoQ activity, actin cytoskeletal reorganization, and invasion potential. |
| Species | Human |
| Editing Sites | 1 |
| Disease | Colorectal Cancer; |
| Description | Among colorectal adenocarcinoma patients, recurrence was more frequently observed in patients with tumors having edited RHOQ transcripts. The RNA editing in RHOQ is asparagin (AAT) to serine (AGT) at residue 136. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | P17081(Uniport); NM_012249 (NM id); 23433 (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | AA Seq Position | NT Seq Position | Codon Change | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Interaction | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | CDS | 136 | 726 | AAU->AGU | N->S | Nonsynonymous substitution | Increased | Mucosa | Increase the RhoQ activity, actin cytoskeletal reorganization, and invasion potential | Recurrence is more frequently in patients with tumors having edited RHOQ transcripts. | Promote recurrence |