mRNA - EDK - BIG Data Center

TPH2

Gene symbol	TPH2
Aliases	-
Protein Name	Tryptophan 5_hydroxylase 2
Function	This subpathway is part of the pathway serotonin biosynthesis, which is itself part of Aromatic compound metabolism. View all proteins of this organism that are known to be involved in the subpathway that synthesizes serotonin from L-tryptophan, the pathway serotonin biosynthesis and in Aromatic compound metabolism.
Species	Human
Editing Sites	5
Disease	Psychiatric Disease;
Description	RNA editing was shown to inhibit the enzymatic activity of both TPH2 splice variants, the complex fine tuning of central nervous system 5-HT biosynthesis by TPH2 alternative splicing and RNA editing. RNA editing is involved in the etiology of the psychiatric disease.
RADR	RADAR
REDIportal	REDI portal
External links	Q8IWU9(Uniport); NM_173353 (NM id); 121278 (NCBI gene id); GeneCard; GTEx
Sequence

Editing sites

Enzyme	Editing type	Region	NT Seq Position	Molecular Consequence	Editing Level	Tissue	Editing Effect	Phenotype	Disease name	PMID
APOBEC	A-to-I	Exonic	711	Alternative splicing	Present	Brain	RNA editing is shown to inhibit the enzymatic activity of both TPH2 splice variants, the complex fine-tuning of central nervous system 5-HT biosynthesis by TPH2 alternative splicing and RNA editing.	Affect disease processing	Psychiatric Disease;	20126463
APOBEC	C-to-U	Exonic	830	Alternative splicing	Present	Brain	RNA editing is shown to inhibit the enzymatic activity of both TPH2 splice variants, the complex fine-tuning of central nervous system 5-HT biosynthesis by TPH2 alternative splicing and RNA editing.	Affect disease processing	Psychiatric Disease;	20126463
APOBEC	A-to-I	Exonic	1297	Alternative splicing	Present	Brain	RNA editing is shown to inhibit the enzymatic activity of both TPH2 splice variants, the complex fine-tuning of central nervous system 5-HT biosynthesis by TPH2 alternative splicing and RNA editing.	Affect disease processing	Psychiatric Disease;	20126463
APOBEC	G-to-A	Exonic	1322	Alternative splicing	Present	Brain	RNA editing is shown to inhibit the enzymatic activity of both TPH2 splice variants, the complex fine-tuning of central nervous system 5-HT biosynthesis by TPH2 alternative splicing and RNA editing.	Affect disease processing	Psychiatric Disease;	20126463
APOBEC	A-to-I	Exonic	711	Alternative splicing	Present	Brain	RNA editing is shown to inhibit the enzymatic activity of both TPH2 splice variants, the complex fine-tuning of central nervous system 5-HT biosynthesis by TPH2 alternative splicing and RNA editing.	Affect disease processing	Psychiatric Disease;	20126463