EDK
Editome Disease Knowledgebase
hsa-miR-221
| miRNA ID | hsa-miR-221 | Editing sites | 2 |
|---|---|
| Species | Human |
| miRBase | MI0000298 |
| PMID | 25582055 |
| Description | ADAR2 edits miR-221 precursors and decreases the expression of the corresponding mature onco-miRNAs in vivo and in vitro, with important effects on cell proliferation and migration. |
| Disease | Glioblastoma; |
| Sequence |
Editing sites
| Enzyme | Editing Type | Editing-Level | Molecular Effect | Relationship | Correlation | Editing Effect | Phenotype | Disease | PMID |
|---|---|---|---|---|---|---|---|---|---|
| ADAR2 | A-to-G | Increase | miRNA expression change | Causative | Positive | The edited miR-221 affects cell proliferation and migration. | Affect tumor migration and invasion | 25582055 |