EDK
Editome Disease Knowledgebase
hsa-miR-381
| miRNA ID | hsa-miR-381 | Editing sites | 2 |
|---|---|
| Species | Human |
| miRBase | MI0000789 |
| PMID | 26640150 |
| Description | The A-to-I editing on the proposed targets contributed to the phenotype of lung cancer cells: we found that the overexpression of the edited miR-381 transcripts significantly enhances the growth of tumor cells in comparison with the transfection of the unedited transcripts. |
| Disease | Lung Cancer; |
| Sequence |
Editing sites
| Enzyme | Editing Type | Editing-Level | Molecular Effect | Relationship | Correlation | Editing Effect | Phenotype | Disease | PMID |
|---|---|---|---|---|---|---|---|---|---|
| ADAR1 | A-to-G | Increase | miRNA expression change | Causative | Positive | RNA editing promotes the growth of tumor cells in comparison with the transfection of the unedited transcripts. | Promote the tumor cell growth | 26640150 | |
| ADAR1 | A-to-G | Increase | miRNA expression change | Causative | Positive | RNA editing promotes the growth of tumor cells in comparison with the transfection of the unedited transcripts. | Promote the tumor cell growth | 26640150 |