EDK
Editome Disease Knowledgebase
hsa-mir-214
| miRNA ID | hsa-mir-214 | Editing sites | 2 |
|---|---|
| Species | Human |
| miRBase | MI0000290 |
| PMID | 24386085 |
| Description | miR-214 frequently deregulate in Hepatocellular Carcinoma. ADAR2-mediate editing event caused a decrease of the RNA transcript complementary to pri-miR-214, which led to the decrease of pri-miR-214 and miR-214 and resulted in the increased protein level of its novel target gene Rab15. RNA editing is a novel mechanism for regulating the biogenesis of specific miRNAs during hepatocarcinogenesis. |
| Disease | Hepatocellular Carcinoma; |
| Sequence |
Editing sites
| Enzyme | Editing Type | Editing-Level | Molecular Effect | Target Change | Regulation Target | Relationship | Correlation | Editing Effect | Phenotype | Disease | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ADAR2 | U-to-C | Increase | miRNA and its target gene expression change | Rab15->Rab15 | Increase Rab15 expression | Correlated | Not determine | The decrease of pri-miR-214 and miR-214 increase protein level of its novel target gene Rab15. | Affect hepatocarcinogenesis | 24386085 | |
| ADAR2 | U-to-C | Increase | miRNA and its target gene expression change | Rab15->Rab15 | Increase Rab15 expression | Correlated | Not determine | The decrease of pri-miR-214 and miR-214 increase protein level of its novel target gene Rab15. | Affect hepatocarcinogenesis | 24386085 |