| Human parainfluenza virus type 3 |
human |
NA |
Phosphoprotein (P) gene |
Antiviral |
Fever; Cough |
|
- Edited Gene Alias: P gene
- Editing Site: NA
- Editing Type: G insertion
- Amino Acid Change: NA
- Editing Level: Present
- Molecular Consequence: NA
- Correlation: Negative
- Description: The addition of a single nucleotide at the D editing site results in the introduction of a stop codon and the subsequent truncation of the P cistron; Addition of two nontemplated nucleotides at the D editing site: this portion of the P cistron would not be expected to be functional; the insertion of three (or multiples of three): the accession or fusion of three cistrons, the intact P proteins, truncated P (P,) proteins, and a fused P/D protein.
- PMID: 1310183
|
| Human parainfluenza virus type 3 |
Mouse |
NA |
Phosphoprotein |
Inhibit viral RNA synthesis |
Fever; Cough |
|
- Edited Gene Alias: P gene
- Editing Site: NA
- Editing Type: G insertion
- Amino Acid Change: NA
- Editing Level: Present
- Molecular Consequence: NA
- Correlation: Negative
- Description: The human parainfluenza virus type 3 (HPIV3) phosphoprotein (P) gene is unusual as it contains an editing site where nontemplated ribonucleotide residues can be inserted. This RNA editing can lead to the expression of the viral P, PD, putative W, and theoretical V protein from a single gene. During the replication of most paramyxoviruses, additional proteins are expressed from the multicistronic P gene by insertion of nontemplated G residues at a specific editing site. This RNA editing leads to a translational frameshift and the generation of chimeric polypeptides with the same N-terminus but different C-termini.
- PMID: 23686695
|
EDK
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