GEN – Gene Expression Nebulas

Credit by: Yuansheng Zhang, Tongtong Zhu

The Gene Expression Nebulas (GEN) (https://ngdc.cncb.ac.cn/gen/) is a comprehensive data portal of gene expression profiles across various biological conditions. Based on a set of ontologies on disease, tissue and cell type, GEN integrates large-scale publicly available bulk and single-cell RNA sequencing datasets with strict criteria from raw sequence repositories. All high-quality sequencing data are processed with standardized pipeline and manually curated based on meta information from public databases as well as publications. Till August 2020, GEN has integrated human expression profiles across 25,618 experiments and 99 tissues from 148 studies, including 22,116 single-cell experiments that cover 410,149 cells in 31 diseases and 47 development stages. In addition, GEN has also integrated plant expression profiles in 35 organs from 49 studies, including 645 experiments for rice, 506 for soybean, 462 for sorghum and 78 for wheat, respectively. GEN provides convenient and user-friendly web interfaces for data browsing, search, visualization and batch downloading, and also equips with a suite of analysis tools for differential gene expression, functional enrichment, regulatory network, and cell type annotation.

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