Genome-scale profiling of circulating cell-free DNA signatures for early detection of hepatocellular carcinoma in patients with cirrhosis
Release date:
2021-04-16
Description:
A case control study recruited patients with HCC, liver cirrhosis and healthy controls. Four genomic features of cell-free DNA (cfDNA), including nucleosome footprint (NF), fragmentation, base mismatch (BM) and 5-hydroxymethylcytosines (5hmc) were profiled by low-pass whole genome sequencing (2x) and hydroxymethylcytosines enrichment sequencing. Training and validation cohorts helped develop the integrated diagnostic model and test cohort was used to evaluate its performance.
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HRA000199.xlsx