A human immune cell landscape in aging and COVID-19
Release date:
2020-08-14
Description:
Age-associated changes in immune cells have been linked with increased risk for infection and cancer. However, a global and detailed characterization of the changes human immune cells undergo with age is lacking. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old research subjects and patients with COVID-19. We found an aging reprogramed immune cell landscape. Notably, aging increased senescent hallmark genes and coronavirus susceptibility gene expression in cell-subtype specificity. Most impressively, COVID-19 increased aging-induced immune cells polarization, inflammation genes and senescent hallmark genes upregulation. An aging-associated dysregulated immune system and upregulated SARS-CoV-2 susceptibility gene expression may account for susceptibility and increased vulnerability of COVID-19 in the elderly.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
Zhongshan eye center is the State Key Laboratory of Ophthalmology. The goal of building a world-class ophthalmic laboratory is proposed. According to the requirements of "opening, mobility, union and competition", further refine the research direction, introduce talents, build an international team, improve working conditions, coordinate basic and clinical work, strictly regulate management, and create a research atmosphere of courage, inclusiveness and cooperation
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HRA000203.xlsx