Genomic Profiling of Chinese Urothelial Carcinoma Patients
Urothelial carcinoma (UC) is the most common genitourinary malignancy in China. In this study, we studied the genomic features in Chinese UC patients and investigated the concordance of genetic alterations between serum circulating tumor-free DNA (ctDNA) and matched tumor tissue. A total of 112 UC patients were enrolled, and 31 of which were upper tract UC (UTUC) and 81 were UC of the bladder (UCB), respectively. Utilizing target next-generation sequencing, we analyzed genomic alterations of 92 selected genes.