Single cell analysis coupled with TCR sequencing of gastric tumor reveals complex intercellular interaction and an alternative T-cell exhaustion trajectory
Release date:
2022-08-01
Description:
Complex cellular composition and intercellular interaction networks have been associated with the development and progression of several cancers, while gastric cancer (GC) has remained poorly characterized. To dissect characteristics specific to the GC tumor microenvironment, we generated an atlas of 166,533 cells from 10 GC patients with matched normal tissues and blood, profiling epithelial, immune, and stromal compartments. This analysis revealed vast cellular phenotypic remodeling in TME.
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HRA000704.xlsx