Association between NR3C1 mutations and glucocorticoid resistance in children with acute lymphoblastic leukemia
Release date:
2021-07-30
Description:
The outcome of patients with relapsed/refractory ALL remains unsatisfactory, despite these patients generally receive more intense therapy. Glucocorticoid (GC) resistance is a leading cause of treatment failure and relapse in ALL. Abnormal NR3C1 transcription and/or translation are strongly associated with GC resistance, but the underlying molecular mechanism and the clinical value of NR3C1 alterations with GC resistance in ALL treatment remain unclear.
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